Biological effects of formulation containing curcuminoids and Bidens Pilosa L. in oral carcinoma cell line

نویسندگان

چکیده

FITOPROT, which contains curcuminoids and Bidens pilosa L. extract, is an innovative mucoadhesive formulation indicated for the topical treatment of chemoradiotherapy-induced oral mucositis (OM) in patients with advanced visible squamous cell carcinoma. The used as a mouthwash directly on tumor tissue neoplasms, without triggering cancer proliferation or invasiveness. Thus, aim this study was to evaluate biological effects FITOPROT carcinoma line (SCC-4). viability SCC-4 cells assessed after exposure using MTT reduction assay. cycle progression death parameters were evaluated flow cytometry. In addition, inflammatory profile cytometric bead array (CBA) promoted concentration-dependent decrease arrest at G2/M phase (p < 0.05). Mitochondrial membrane potential also altered 0.05), parallel VEGF IL-8 production = 0.01 p 0.05, respectively). summary, results indicate that reduces viability, promotes arrest, modulates mitochondrial potential, exhibits antiangiogenic anti-inflammatory properties, thus indicating its use OM tumors mouth.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Anti-adult T-cell leukemia effects of Bidens pilosa.

We evaluated the effects of Bidens pilosa, a plant found in tropical and subtropical regions, and investigated the molecular pathways responsible for the anti-adult T-cell leukemia (ATL) effect. Water extracts of B. pilosa had growth suppressive effects on human T-cell leukemia virus type 1 (HTLV-1)-infected T-cell lines and ATL cells. B. pilosa extracts arrested cells in G1 cell cycle and indu...

متن کامل

Bidens pilosa Formulation Improves Blood Homeostasis and β-Cell Function in Men: A Pilot Study

B. pilosa has long been purported to have antidiabetes activity, but despite the advancement in phytochemistry and animal models of diabetes, no human clinical trials have been conducted to date. Here, we evaluated the effect of a B. pilosa formulation on fasting blood glucose (FBG), fasting serum insulin, and glycosylated hemoglobin A1c (HbA1c) in diabetic subjects. The B. pilosa formulation r...

متن کامل

Compilation of secondary metabolites from Bidens pilosa L.

Bidens pilosa L. is a cosmopolitan annual herb, known for its traditional use in treating various diseases and thus much studied for the biological activity of its extracts, fractions and isolated compounds. Polyacetylenes and flavonoids, typical metabolite classes in the Bidens genus, predominate in the phytochemistry of B. pilosa. These classes of compounds have great taxonomic significance. ...

متن کامل

Mucoadhesive formulation of Bidens pilosa L. (Asteraceae) reduces intestinal injury from 5-fluorouracil-induced mucositis in mice

Gastrointestinal mucositis induced during cancer treatment is considered a serious dose-limiting side effect of chemotherapy and/or radiotherapy. Frequently, interruption of the cancer treatment due to this pathology leads to a reduction in cure rates, increase of treatment costs and decrease life quality of the patient. Natural products such as Bidens pilosa L. (Asteraceae), represent a potent...

متن کامل

Brazilian Bidens pilosa Linné yields fraction containing quercetin-derived flavonoid with free radical scavenger activity and hepatoprotective effects

Bidens pilosa is a plant used by Amazonian and Asian folks for some hepatopathies. The hydroethanol crude extract and three fractions were assessed for antioxidant and hepatoprotective effects. Higher levels of scavenger activity on the 1,1-diphenyl-2-picrylhydrazyl radical, inhibition of deoxyribose oxidation and lipid peroxidation in vitro were detected for the ethyl acetate fraction (IC(50)~...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Brazilian Oral Research

سال: 2021

ISSN: ['1806-8324', '1807-3107']

DOI: https://doi.org/10.1590/1807-3107bor-2021.vol35.0063