Biological effects of formulation containing curcuminoids and Bidens Pilosa L. in oral carcinoma cell line

FITOPROT, which contains curcuminoids and Bidens pilosa L. extract, is an innovative mucoadhesive formulation indicated for the topical treatment of chemoradiotherapy-induced oral mucositis (OM) in patients with advanced visible squamous cell carcinoma. The used as a mouthwash directly on tumor tissue neoplasms, without triggering cancer proliferation or invasiveness. Thus, aim this study was to evaluate biological effects FITOPROT carcinoma line (SCC-4). viability SCC-4 cells assessed after exposure using MTT reduction assay. cycle progression death parameters were evaluated flow cytometry. In addition, inflammatory profile cytometric bead array (CBA) promoted concentration-dependent decrease arrest at G2/M phase (p < 0.05). Mitochondrial membrane potential also altered 0.05), parallel VEGF IL-8 production = 0.01 p 0.05, respectively). summary, results indicate that reduces viability, promotes arrest, modulates mitochondrial potential, exhibits antiangiogenic anti-inflammatory properties, thus indicating its use OM tumors mouth.